11β-Hydroxysteroid Dehydrogenase 1: Translational and Therapeutic Aspects
نویسندگان
چکیده
منابع مشابه
11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline.
Excess cortisol levels are linked with brain atrophy and cognitive decline in older people. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) potently amplifies intracellular glucocorticoid action by converting inert cortisone to active cortisol, but any causal importance in brain aging is unexplored. We tested the hypotheses that higher systemic 11β-HSD1 activity predicts brain atrophy and co...
متن کامل11β-Hydroxysteroid Dehydrogenase Type 1 and the Metabolic Syndrome
In the past few years, efforts are being made to unravel the mechanisms endowed with the metabolic disturbances associated with obesity that predispose to the metabolic syndrome (MetSyn). The special pathogenic role of liver and visceral adipose tissue (VAT) functions has been particularly intriguing, and many hypotheses have been advanced to explain this association. Tissue-specific actions of...
متن کامل11β-Hydroxysteroid dehydrogenase type 1: potential therapeutic target for metabolic syndrome.
Obesity and associated metabolic syndrome is one of the greatest health threat to the modern society. Cortisol excess and the glucocorticoid receptor signaling pathway in the metabolically active tissues have been implicated in the development of diabetes and obesity. The key enzyme in the regeneration of intracellular cortisol is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD1 inc...
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Glucocorticoids are used to treat a number of human diseases but often lead to insulin resistance and metabolic syndrome. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that catalyzes the intracellular conversion of cortisone to physiologically active cortisol. Despite the known role of 11β-HSD1 and active glucocorticoid in causing insulin resistance, the molecular mechanism...
متن کامل11β-Hydroxysteroid Dehydrogenase-2 and Salt-Sensitive Hypertension.
1335 Glucocorticoid intracellular metabolism, catalyzed by the 2 isozymes of 11β-hydroxysteroid dehydrogenase (11βHSD), determines the corticosteroid action on target tissues. 11β-HSD1 functions as a reductase in most cells and catalyzes the regeneration of active glucocorticoids, thereby amplifying their action. This isozyme is widely expressed in liver, adipose tissue, muscle, pancreatic isle...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2013
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2012-1050